With some of America's closest trading partners imposing retaliatory measures, Trump's approach to tariffs has unsettled financial markets and strained relations between the White House and the Chamber. The new campaign is an aggressive effort by the business lobbying giant. Using a state-by-state analysis, it argues that Trump is risking a global trade war that will hit the wallets of US consumers.

The 3-million-member Chamber used to be a close ally of US Presidents of the Republican Party. Trade tensions escalated when the US imposed steel and aluminum tariffs on the US's allies.